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Post-traumatic stress disorder (PTSD) has been associated with elevated levels of the pro-inflammatory marker C-reactive protein (CRP) and with high rates of inflammatory disorders (including cardiovascular and metabolic disorders). Also, elevated CRP levels before military deployment have been found to predict increased risk for PTSD, and individual differences in CRP level are partly attributable to single nucleotide polymorphisms (SNPs) within the CRP gene. These investigators examined associations among six SNPs in CRP, CRP level, PTSD diagnosis, PTSD symptom rating, and fear-related startle response (a marker for hypervigilance).
The study population comprised 187 patients recruited from primary-care clinics of an inner-city U.S. hospit…