Clinical Significance of Non-IRA Disease in STEMI Patients

Obstructive coronary artery disease in a non-infarct artery was associated with increased mortality in a meta-analysis of patients with ST-segment elevation myocardial infarction, but the optimal therapeutic strategy remains unclear.

In previous studies, about 40% to 65% of patients presenting with ST-segment elevation myocardial infarction (STEMI) had multivessel coronary artery disease (CAD). Results were conflicting regarding conservative versus aggressive treatment for non–infarct-related artery (IRA) disease (Am Heart J 2004; 148:493, JACC Cardiovasc Interv 2010; 3:22, and NEJM JW Cardiol Sep 1 2013).

To investigate the rate, extent, location, and 30-day mortality of obstructive non-IRA disease (stenosis of ≥50%), researchers conducted a retrospective study of 28,282 patients with valid angiographic information out of 68,765 STEMI patients pooled from a sample of eight randomized clinical trials. To assess the generalizability of trial-based results, the researchers…

Reviewing Author

Beat J. Meyer, MD

Disclosures

Leadership positions in professional societiesBern Heart Foundation (President); International Academy of Medicine, Bern, Switzerland (Director)

Beat J. Meyer, MD

Disclosures

Leadership positions in professional societiesBern Heart Foundation (President); International Academy of Medicine, Bern, Switzerland (Director)

Clinical Significance of Non-IRA Disease in STEMI Patients

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Reviewing Author