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Statins interfere with production of coenzyme Q10 (CoQ10), which has a role in muscle metabolism. Thus, CoQ10 supplementation has been proposed as a way to mitigate myalgia associated with statin therapy.
Researchers examined the efficacy of this intervention in a meta-analysis of six placebo-controlled, randomized trials (302 patients). Five trials enrolled patients with muscle symptoms; the sixth trial enrolled asymptomatic patients but examined the effects of CoQ10 on creatine kinase (CK) blood levels, as did several of the other trials. Study durations ranged from 1 month to 3 months, and CoQ10 doses ranged from 100 mg to 400 mg daily. CoQ10 — regardless of dose — had no significant effect on muscle symptoms or CK levels.
In a new publish…