Noninvasive Ventilation Often Is Paramount for Severe COPD Exacerbations

Compared with invasive ventilation for chronic obstructive pulmonary disease exacerbations, noninvasive positive pressure ventilation was associated with lower in-hospital mortality, length of stay, and cost.

Based on meta-analysis of randomized, controlled trials, noninvasive positive pressure ventilation (NPPV) is the only intervention that improves mortality in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD; Cochrane Database Syst Rev 2004; CD004104). However, many patients who are eligible for this intervention go untreated, and the benefits of NPPV in routine clinical practice remain incompletely defined.

Researchers evaluated data from a retrospective cohort of >25,000 patients (at 420 U.S. hospitals) who were admitted with COPD exacerbations and received either NPPV or invasive mechanical ventilation within the first 2 days of hospital admission. In propensity-matched comparisons versus invasive vent…

Reviewing Authors

Daniel D. Dressler, MD, MSc, SFHM, FACP

Disclosures

RoyaltiesMcGraw-Hill; Elsevier

Editorial BoardsMedical Clinics of North America; Caribbean Medical Journal International Advisory Panel (2021–2026)

Daniel D. Dressler, MD, MSc, SFHM, FACP

Disclosures

RoyaltiesMcGraw-Hill; Elsevier

Editorial BoardsMedical Clinics of North America; Caribbean Medical Journal International Advisory Panel (2021–2026)

Max Weiner Adelman, BA

Noninvasive Ventilation Often Is Paramount for Severe COPD Exacerbations

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Reviewing Authors