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Neuropathic pain is a serious chronic condition affecting quality of life that can be relieved but not cured. The estimated prevalence is at least 1% to 5% of the general population (Pain Pract 2014; 14:283). Neuropathic pain results from lesions or disease affecting the somatosensory nervous system, either in the periphery or centrally.
To examine the effect of various treatments for neuropathic pain, researchers conducted a systematic review and meta-analysis of randomized, double-blind studies of oral and topical medications. Studies published in peer-reviewed journals since 1966, as well as unpublished trials retrieved from ClinicalTrials.gov and those from websites of pharmaceutical companies, were included.
On the basis of this analysis…