Transmitted and Acquired Antiretroviral Resistance — An Intriguing Analysis

Analysis of resistance data from the Swiss HIV Cohort suggests different sources for the various resistance mutations, with viral fitness the key factor.

Although rates of acquired antiretroviral drug resistance (ADR) have declined in association with the improved effectiveness of contemporary antiretroviral therapy (ART), the overall prevalence of transmitted drug resistance (TDR) has remained relatively unchanged. Now, using Swiss HIV Cohort data from 1998 through 2012, researchers have investigated factors driving both ADR and TDR, with a focus on recently infected, ART-naive individuals.

Overall, the ADR rate among ART-experienced patients peaked at 85% in 1998, then fell continuously to a new plateau of ~38% in 2009. In contrast, during the same period, the overall TDR rate among ART-naive patients increased by about 0.3% per year. Among recently infected, ART-naive patients, TDR prevale…

Reviewing Author

Charles B. Hicks, MD

Disclosures

Consultant / Advisory boardGilead Sciences; ViiV; Merck

RoyaltiesUpToDate, Inc.

Grant / Research supportNIH; Department of Health and Human Services

Charles B. Hicks, MD

Disclosures

Consultant / Advisory boardGilead Sciences; ViiV; Merck

RoyaltiesUpToDate, Inc.

Grant / Research supportNIH; Department of Health and Human Services

Transmitted and Acquired Antiretroviral Resistance — An Intriguing Analysis

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Reviewing Author