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Although endometrial biopsy represents the gold standard for diagnosing endometrial cancer, the procedure is painful and may miss focal endometrial lesions such as polyps. Saline infusion sonography (SIS) is less painful than biopsy for many women (and has a high sensitivity for identifying polyps and other focal intracavitary lesions), but the diagnostic accuracy of biopsy immediately following SIS is uncertain. Investigators attempted to determine if ultrasound-guided endometrial aspiration for biopsy immediately following SIS had good sensitivity and specificity. Study participants were women aged ≥50 with postmenopausal bleeding who also had thickened endometrium or a suspected polyp on a prior ultrasound scan. Data on surgical outcomes…