Newer HCV Regimens Efficacious in HIV/HCV-Coinfected Patients

Two interferon-free hepatitis C virus regimens resulted in high sustained virologic response rates in HIV-coinfected patients.

In the U.S., approximately one third of all patients with HIV infection are coinfected with hepatitis C virus (HCV). HCV-related morbidity and mortality is substantial in this patient population. Newer treatment regimens that are free of interferon (IFN), ribavirin (RBV), or both are promising, but their role in treating coinfected patients has not been well defined. Two recent open-label studies now add to our understanding of their efficacy and tolerability in this population.

Osinusi and colleagues conducted an uncontrolled, partially industry-sponsored, single-center trial in which 50 HCV treatment-naive adults with well-controlled or early HIV infection and HCV genotype 1 infection without cirrhosis received the fixed-dose combination o…

Reviewing Author

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Newer HCV Regimens Efficacious in HIV/HCV-Coinfected Patients

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Reviewing Author