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Imaging-based methods offer noninvasive, less-costly alternatives to liver biopsy sampling for assessing fibrosis in patients with chronic liver disease. To evaluate the diagnostic accuracy of one such method, magnetic resonance elastography (MRE), in staging fibrosis, researchers conducted a systematic review and meta-analysis of individual-level data.
Twelve studies published between 2003 and 2013 were included, all of which compared MRE to liver biopsy analysis (gold standard). Area under the receiver-operating curve (AUC), sensitivity, and specificity were calculated for any fibrosis (stage ≥1), significant fibrosis (stage ≥2), advanced fibrosis (stage ≥3), and cirrhosis (stage 4).
Among 697 patients (60% men; mean age, 55 years; mean bod…