Rectal Colonization with Fluoroquinolone-Resistant E. coli Poses a Major Risk for Infection After Transrectal Prostate Biopsy

In a single-center, observational study, prebiopsy isolation of fluoroquinolone-resistant Escherichia coli from the rectum was associated with a 4.6-fold increased risk for subsequent infection.

Transrectal ultrasound–guided prostate needle biopsy (TPB) is the gold standard for diagnosing prostate cancer. However, the rate of infection — even after recommended prophylaxis with a fluoroquinolone — is 3% to 5% and rising. The increase is thought to be due to the emergence of fluoroquinolone-resistant Escherichia coli, particularly the more virulent sequence type (ST) 131.

To further study this hypothesis, investigators performed a retrospective review involving men who underwent TPB at the San Diego Veterans Affairs Medical Center between January 2010 and February 2014 (N=1638). All received a single 750-mg oral dose of ciprofloxacin 1 hour before the procedure; rectal swabs for culture were collected at the time of biopsy for 914 pat…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Rectal Colonization with Fluoroquinolone-Resistant E. coli Poses a Major Risk for Infection After Transrectal Prostate Biopsy

Topics

Reviewing Author