A randomized, controlled trial demonstrated a proof of concept that topical botulinum toxin can be effective when applied to periorbital skin that has been exposed to ablative fractional CO2 laser treatment.
The usual delivery of botulinum toxin for correction of wrinkles is via injection. Some patients may have concerns about pain or bruising to the crow's feet area. Topical botulinum toxin A has not been effective for wrinkling in this area. To determine whether laser treatment might improve effectiveness, Mahmoud and colleagues studied the effects of topical botulinum toxin applied to the skin of the lateral canthal area immediately after ablative resurfacing with a fractional carbon dioxide laser.
In this randomized, controlled trial, each of 10 patients received toxin and laser to the periorbital wrinkles on one side and saline vehicle and laser to the contralateral side. Rating improvement on the 5-point Crow's Feet Grading Scale, a clinic…
Reviewing Author
DisclosuresConsultant / Advisory boardAmway
Editorial boards JAMA Dermatology; Dermatologic Surgery; Journal of Cosmetic Dermatology; Lasers in Medical Science; Skin Therapy Letter
Leadership positions in professional societies American Academy of Dermatology (Chair, Health Care Finance Committee); American College of Mohs Surgery (Board of Directors); American Society for Dermatologic Surgery (Board of Directors)
DisclosuresConsultant / Advisory boardAmway
Editorial boards JAMA Dermatology; Dermatologic Surgery; Journal of Cosmetic Dermatology; Lasers in Medical Science; Skin Therapy Letter
Leadership positions in professional societies American Academy of Dermatology (Chair, Health Care Finance Committee); American College of Mohs Surgery (Board of Directors); American Society for Dermatologic Surgery (Board of Directors)