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As cancer therapy becomes more effective, understanding its long-term complications becomes increasingly important. To understand the long-term risks for cardiovascular disease (CVD) associated with Hodgkin lymphoma (HL) treatment, investigators in the Netherlands conducted a retrospective cohort study of 2524 patients who had received treatment for HL from 1965 through 1995 before age 51 (median age, 27.3 years) and had survived longer than 5 years after diagnosis.
Of these patients, 81% received mediastinal radiation, and 31% received anthracycline-containing chemotherapy. The outcomes studied were incidence of coronary artery disease (CAD), valvular heart disease (VHD), and congestive heart failure (CHF).
Results at a median follow-up of 2…