Adverse Reactions to Antibiotics Given for Endocarditis Prophylaxis

In England, rates of fatal and nonfatal reactions were 0 and 23 per million courses of amoxicillin and 13 and 149 per million courses of clindamycin, respectively.

Previous endocarditis prophylaxis (EP) guidelines recommended liberal use of prophylactic antibiotics before dental and other invasive procedures for patients with conditions associated with increased endocarditis risk. Because of questionable efficacy and potential risks of such antibiotic use, revised U.S. and European EP guidelines — issued in 2007 and 2009, respectively — restricted prophylaxis to patients with the highest endocarditis risk. The 2008 U.K. National Institute for Health and Care Excellence (NICE) guidelines, however, discouraged EP generally. Now, researchers have analyzed government data on antibiotic prescriptions and adverse drug reactions (ADRs) in England to determine the risk and nature of EP-associated ADRs. Most s…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Adverse Reactions to Antibiotics Given for Endocarditis Prophylaxis

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Reviewing Author