A Swedish cohort study suggests that depression may be a very early symptom of PD or a risk factor but couldn't distinguish between these possibilities.
Parkinson disease (PD) has been linked to subsequent depression, but it remains unknown whether depression is a predisposing risk factor for PD or an early PD symptom, or whether a third factor predisposes to both. Now, researchers have used data from Swedish national registers to explore this issue.
Diagnostic information from 1987 through 2012 was gathered for all Swedish citizens who were aged ≥50 as of December 31, 2005. The final cohort consisted of 140,688 individuals with depression and no prior diagnosis of PD, each of whom was matched with three age- and sex-matched controls who did not have depression. In addition, 540,811 sibling pairs were analyzed.
PD was diagnosed after enrollment in 3260 participants (median interval, 4.5 years…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)