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Granular parakeratosis (GP) was first described in 1991 as an idiopathic disorder of keratinization in the axillae and other intertriginous sites in adults. It is postulated to be triggered by product use or friction coupled with a humid skin environment. Histopathologic changes are diagnostic, revealing parakeratosis with retention of keratohyalin granules in a thickened stratum corneum and with a preserved stratum granulosum. Molecular studies of GP show a basic defect in the processing profilaggrin to filaggrin. Avoidance of occlusive products sometimes leads to resolution of GP.
There are 13 reports of infantile GP, with the rash typically localizing to areas covered by diapers. Now, Turkish investigators describe seven more cases of cli…