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Previous studies have established that a strong relation exists between increasing coronary artery calcium (CAC) scores and additional adverse clinical outcomes. However, most of the literature has been focused on shorter-term prognoses (5-year outcomes). In this single-center observational study, ≥9000 patients without known coronary artery disease (CAD) at baseline underwent CAC evaluations from 1996 through 1999.
Mean follow-up duration was 15 years. Unadjusted all-cause mortality increased steadily with progressively higher CAC scores, ranging from 3% (in participants with scores of 0) to 28% (in participants with scores of ≥1000). After adjustment for CAD risk factors, CAC score remained highly predictive of time to all-cause mortality.…