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To provide estimates of morbidity and mortality associated with various combinations of cardiometabolic conditions, investigators analyzed data from 689,300 participants in the Emerging Risk Factors Collaboration in 91 cohorts across 18 countries collected from 1960 through 2007. Analyses were stratified by sex and adjusted for age and then further adjusted for major cardiovascular risk factors, diet, and socioeconomic status.
During extended follow-up, 135,000 deaths occurred (all-cause mortality rate, 7 per 1000 person-years). For individuals with a history of diabetes, stroke, or myocardial infarction (MI), mortality was much higher (about 16 per 1000 patient-years). For a combination of any two of the factors (diabetes, MI, or stroke), m…