Association Identified Between Genes and Major Depression in Han Chinese

Strongest findings were for a locus on SIRT1 that affects pathways associated with various diseases of aging, including those occurring early in patients with major depression.

Phenotypic variations of major depressive disorder (MDD) and diverse environmental factors confound genetic studies and support investigations of circumscribed populations, such as the Han Chinese women in this study. The study was limited to women because of sex differences in genetic liability to MDD.

Analyses involved 5303 patients with recurrent MDD (mean, 5.6 episodes; age range, 30–60) and no substance use disorders before MDD onset and 5337 controls. Controls had neither personal nor family histories of major psychiatric disorders.

Sparse twofold whole genome sequencing revealed two significant loci on chromosome 10, SIRT1 (minor allele frequency, 45%) and LHPP (minor allele frequency, 26%). Findings were replicated in an independent s…

Reviewing Author

Barbara Geller, MD

Disclosures

Nothing to disclose

Barbara Geller, MD

Disclosures

Nothing to disclose

Association Identified Between Genes and Major Depression in Han Chinese

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Reviewing Author