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Weight loss is recommended by most clinicians for treatment of nonalcoholic steatohepatitis (NASH), though evidence supporting this approach is limited. In two prospective studies, researchers assessed the efficacy of lifestyle modification and surgery in achieving weight loss in this population.
In the first study, 293 patients with histologically proven NASH adopted a low-fat, hypocaloric diet, walked 200 minutes weekly, and attended individual behavioral sessions to promote diet adherence. Based on biopsy samples taken at baseline and week 52, NASH resolved in 25% of patients, the nonalcoholic fatty liver disease activity score decreased in 47%, and 19% experienced regression of fibrosis. The degree of weight loss was independently associ…