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Gastric carcinoma with lymphoid stroma (GCLS) is an uncommon subtype of gastric adenocarcinoma (GA). More than 80% of GCLS tumors have associated Epstein-Barr virus (EBV) infection. To assess and compare clinical and pathologic characteristics of EBV-positive GCLS, EBV-negative GCLS, and non-GCLS GA, investigators at a single hospital in Korea retrospectively identified 274 patients with GCLS and 822 age-matched and sex-matched controls with GA. The prevalence of GCLS was 1.7%.
Eighty-six percent of patients had EBV-positive GCLS. These patients had better disease-specific 10-year survival rates compared with patients with EBV-negative tumors (89.1 vs. 66.9; P=0.009). Ten-year survival was numerically but not statistically higher in patients…