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Borderline personality disorder (BPD) is increasingly viewed as one of a spectrum of disorders of adapting to dysregulated internal emotional response, which may be reflected partly in the patient's impaired awareness of internal physiology. To measure the latter, investigators in Germany studied heartbeat evoked potentials (HEPs) — the concordance between electroencephalography-evoked potentials and R waves on electrocardiography — in 34 unmedicated BPD patients, 17 unmedicated patients with remitted BPD, and 31 normal controls.
Mean HEP amplitudes were significantly lower in active BPD patients than controls, especially at the parietal and occipital electrodes; mean HEP amplitude in patients with remitted BPD was intermediate between the t…