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Orthostatic hypotension (OH) is defined conventionally as a drop in blood pressure (BP) of at least 20 mm Hg systolic or 10 mm Hg diastolic within 3 minutes of standing. When this occurs after 3 minutes, delayed OH (DOH) is present. In 2006, researchers found that, among 230 patients who had been referred for autonomic testing for various reasons, 50 had OH, 58 had DOH, and 122 had neither. Now, the authors provide 10-year follow-up data.
Ten-year mortality was 64% in patients with OH, 29% in patients with DOH, and 9% among 75 age- and sex-matched patients without OH or DOH from the original cohort. Among 48 DOH patients with follow-up data, 26 progressed to OH, and 14 of the latter developed α-synucleinopathies (i.e., Parkinson disease, dem…