Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction

The NEAT trial suggests that nitrates adversely affect activity levels in these patients.

In patients with heart failure and preserved left ventricular ejection fraction (HF-pEF), effective approaches to improving outcomes have been elusive. Oral nitrates appear to improve activity tolerance in HF patients with reduced ejection fraction, but their effect in patients with HF-pEF is not known. Researchers conducted this multicenter, blinded, placebo-controlled crossover trial to assess the effect of oral nitrates on exercise tolerance in 110 patients with HF-pEF (mean age 69 years; 57% women) from 20 U.S. sites. All had a left ventricular ejection fraction ≥50%, objective evidence of heart failure, and reported impaired activity due to symptoms of dyspnea, fatigue, or chest pain. Patients were randomized to receive 6 weeks of plac…

Reviewing Author

Frederick A. Masoudi, MD, MSPH, FACC, FAHA

Disclosures

Consultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research

Grant/Research SupportNational Heart, Lung, and Blood Institute

Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)

Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)

Frederick A. Masoudi, MD, MSPH, FACC, FAHA

Disclosures

Consultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research

Grant/Research SupportNational Heart, Lung, and Blood Institute

Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)

Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)

Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction

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Reviewing Author