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The benefit of population-based screening for melanoma has been somewhat of a controversial issue. Results of early studies showing reduced melanoma mortality following general population screening failed to stand up to longer-term scrutiny. Better-targeted screening of high-risk individuals is another approach but requires easily accessible methods for initial risk prediction. High total mole count is a known risk factor for melanoma, but counting the whole body is difficult and time-consuming; investigators recently looked at partial mole counts in specific anatomic regions to determine the best surrogate for total mole enumeration.
The investigators examined data on nevus count in 3694 healthy female Caucasian twins (mean age, 47) from a …