Oxybutynin for Hyperhidrosis

Excess sweating was improved significantly compared with placebo.

Oxybutynin is an anticholinergic medication indicated for treatment of overactive bladder. As might be predicted, it also has beneficial effects on overactive sweating.

A prospective, randomized 6-week trial compared low doses of oxybutynin to placebo for treatment of hyperhidrosis. The investigators enrolled 62 consecutive patients with localized or generalized hyperhidrosis. All patients had grade 2 or greater palmar, plantar, axillary, facial, or truncal primary hyperhidrosis as assessed by the Hyperhidrosis Disease Severity Score (HDSS). Participants initially received either oxybutynin or placebo 2.5 mg/day. If hyperhidrosis was not controlled, the dose was increased to 5.0 mg/day on day 4 and to 7.5 mg/day on day 8. The primary endpoin…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)