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As men age, their blood testosterone levels generally decline, often to levels in the low or low-normal ranges specified by commercial laboratories. Testosterone supplementation is being prescribed increasingly for such men, some of whom report “aging-male symptoms.” Although testosterone supplementation undoubtedly improves aging-male symptoms and sexual function in men who have overt primary or secondary hypogonadism, the value of supplementation in other men has not been established.
A multi-institutional team conducted a randomized trial of 308 men (age, ≥60) with low or low-normal total testosterone (100–400 ng/dL) or free testosterone (<50 pg/mL), irrespective of symptoms. Participants were treated with either testosterone gel (dose ti…