Potential Diagnostic Tools in the Diagnosis of Sézary Syndrome

Thymocyte selection–associated high-mobility group box protein is promising as a marker for Sézary Syndrome

Sézary syndrome (SS), a cutaneous T-cell lymphoma, involves clonal expansion of neoplastic T cells of skin and peripheral blood. These authors examined the use of two biomarkers — thymocyte selection–associated high-mobility group box protein (TOX) and C-MYC — for differentiating SS from erythrodermic dermatitis.

The authors studied 15 SS and 17 erythrodermic dermatitis biopsies. Strong nuclear staining for TOX in more than 50% of skin-infiltrating T cells was seen in 87% of the SS cases. Strong nuclear staining did not appear in erythrodermic dermatitis cases, but weak nuclear staining appeared in 11% to 50% of T cells in these samples. C-MYC had similar staining patterns in SS and erythrodermic dermatitis. Epidermotropism was seen in 66% o…

Reviewing Author

Angelica Selim, MD

Disclosures

Grant / Research support NIH/NCI, The Plastic Surgery Foundation

Angelica Selim, MD

Disclosures

Grant / Research support NIH/NCI, The Plastic Surgery Foundation

Potential Diagnostic Tools in the Diagnosis of Sézary Syndrome

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Reviewing Author