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The majority of influenza vaccines available are grown in hens' eggs and may contain trace amounts of egg protein. After studies showed its safety in egg-allergic patients, in 2012 the CDC recommended that patients with mild egg allergy (only hives) can safely receive the injectable inactivated influenza vaccine, and that those with severe egg allergy should receive it from a clinician experienced in treating anaphylaxis. The CDC still does not recommend the intranasal live attenuated influenza vaccine (LAIV) for egg-allergic patients.
To examine the safety of LAIV in children with egg allergy, investigators recruited 779 children and adolescents (age range, 2–18 years) from U.K. allergy centers to participate in an open-label study. Thirty-…