In HIV-infected pregnant women who started therapy before conception and maintained virologic suppression, the rate of perinatal transmission was essentially zero.
One of the major successes of HIV prevention is the use of antiretroviral therapy (ART) in HIV-infected pregnant women to reduce rates of perinatal transmission. Now, investigators in France have quantified the effect of starting ART before conception on the likelihood of perinatal transmission. The HIV status of 8075 infants born to infected women from 2000 to 2011 in the French Perinatal Cohort was assessed. All mothers had received ART during pregnancy and did not breast-feed.
No perinatal transmission occurred in the 2651 infants whose mothers began ART before conception, continued treatment throughout pregnancy, and had viral loads <50 copies/mL near the time of delivery. Starting ART later in pregnancy and having a maternal viral load …
Reviewing Author
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)