Dysplasia in Barrett Esophagus — What Biopsy Sampling Approach Is Best?

It might not be the current standard.

Optimizing biopsy sampling technique in endoscopic screening and surveillance of Barrett esophagus (BE) for dysplasia is key to accurately stratifying risk and guiding best-management strategies. Current guidelines recommend four-quadrant biopsies at 2-cm intervals in patients without dysplasia (every 1 cm if prior dysplasia) and no repeat endoscopy at 1 year if negative for dysplasia (NEJM JW Gastroenterol Dec 18 2015; [e-pub] and Am J Gastroenterol 2015 Nov 3; [e-pub]) but are not based on evidence of where dysplasia is most often found in the BE segment.

To examine the distribution of dysplasia prevalence in different BE segment locations, investigators conducted a post-hoc analysis of data from 157 patients in whom dysplastic BE was diag…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors