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Most guideline-recommended drugs for preventing migraine are only moderately effective and have substantial side effects (Neurology 2012; 78:1337). In this study, researchers in Boston tested a novel drug combination for migraine prophylaxis — simvastatin plus vitamin D. The idea came from two observations: First, because migraine is associated with excess risk for vascular disorders, propensity to migraine might be reduced by statins, which improve endothelial function. Second, in a recent observational study, statin use was associated with lower prevalence of “severe headache or migraine” in people with higher serum vitamin D levels (Cephalalgia 2015; 35:757).
Fifty-seven adults with episodic migraine (4–14 migraine days per month) were ra…