Blood Pressure During Sleep, Amyloid Burden, and Cerebral Blood Flow Regulation in Amnestic Mild Cognitive Impairment

Blood pressure typically dips in association with parasympathetic responses during sleep. This study was conducted to investigate whether alterations in this natural dipping pattern are associated with amyloid deposition and cerebral blood flow regulation in amnestic mild cognitive impairment (aMCI), which can be caused by Alzheimer disease pathology. Forty participants with aMCI (age range, 55–80 years) underwent ambulatory 24-hour monitoring of blood pressure, which was recorded every 30 minutes during wakefulness and every 60 minutes during sleep. Amyloid deposition was determined by calculating a standardized uptake value ratio (SUVR) from 18-F-florbetapir positron emission tomographic imaging. Cerebral blood flow regulation was determi…