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Women with suspected uncomplicated urinary tract infections (UTIs) are usually treated with antibiotics, even though this condition is often self-limited. Indeed, although prior research has shown that placebo or delayed antibiotics (compared with immediate antibiotics) prolonged resolution of symptoms and bacterial clearance, no serious UTI-associated complications were observed in any treatment group (NEJM JW Infect Dis Apr 2010 and BMJ 2010; 340:199). German investigators determined whether managing symptoms of uncomplicated UTI with ibuprofen could lower the rate of antibiotic prescriptions safely in 500 women (age range, 18–65) with suspected UTIs that are uncomplicated (defined as dysuria or frequency/urgency without upper-tract signs…