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Given the increase in prevalence of autism spectrum disorders (ASDs), much attention has turned to understanding associations and potential causes of these disorders, with particular interest in perinatal exposures. Canadian investigators used data from a population-based registry to explore associations between maternal antidepressant use during pregnancy and ASDs in offspring.
Among >145,000 term singleton infants, 0.7% had at least one diagnosis of ASD between birth and the end of the follow-up period (mean, 6 years). Mean age at first diagnosis was 2 years. After accounting for measured potential confounders (maternal sociodemographic characteristics, history of maternal psychiatric and physical conditions, and infant characteristics), m…