β-HPV and Cutaneous Squamous Cell Carcinoma: Correlation or Causation?

This meta-analysis found significant correlation between positive β-HPV serology or DNA and cuSCC but does the protein have a direct pathogenic role?

The association between β-genus human papilloma virus (β-HPV) and cutaneous squamous cell carcinoma (cuSCC) is controversial. It is well known that the β-HPV viruses (responsible for most cervical and anogenital SCC) elaborate viral oncoproteins that block cellular tumor-suppressor proteins, such as P53. Molecular mechanisms explaining how β-HPV might contribute to carcinogenesis remain unclear, although some epidemiological evidence correlates exposure and cuSCC risk.

To help address this, Chahoud and colleagues performed a comprehensive meta-analysis of studies published through June 2014. Data from 14 studies, including 3122 adult immunocompetent individuals with cuSCC and 6020 controls without, were pooled. Serology was available for all…

Reviewing Author

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology

β-HPV and Cutaneous Squamous Cell Carcinoma: Correlation or Causation?

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Reviewing Author