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In recent clinical trials, manual thrombectomy during primary percutaneous coronary intervention (PCI) did not help patients with ST-elevation myocardial infarction (STEMI) but was associated with an increase in stroke. Microvascular obstruction in acute MI and during coronary intervention remains an unresolved problem. To learn whether manual thrombus aspiration reduces microvascular obstruction in patients with STEMI presenting late after symptom onset, researchers conducted a single-center study sponsored by the manufacturer of an aspiration thrombectomy catheter.
The 152 patients with sub-acute STEMI presenting ≥12 and ≤48 hours after symptom onset were randomized to primary PCI with or without manual thrombus aspiration. Mean time betwe…