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Squamous cell carcinoma of the vulva (vSCC) represents 5% of gynecological tumors arising in a patient with human papillomavirus (HPV) infection or dermatitis (e.g., lichen sclerosus). Certain tumor features can predict survival, but it is difficult to assess likelihood of recurrence.
The authors reviewed the cases of 92 women (mean age, 64) with stage I vSCC. Immunohistochemical stains for p53 and p16 and high-risk HPV PCR testing were performed. Half of these tumors were smaller than 2 cm; 45% had a depth of invasion of more than 5 mm; three quarters had mixed pushing and infiltrative borders; 6 patients had lymphovascular invasion. Recurrence was seen in 39%. Parameters such as age, depth of invasion, lymphatic/vascular invasion, growth p…