Sex Differences in Outcomes After TAVR

Women may fare better than men after transcatheter aortic valve replacement, according to a secondary analysis from the PARTNER trials.

Female sex is associated with poorer outcomes after surgical aortic valve replacement. What about after transcatheter aortic valve replacement (TAVR)? To find out, investigators conducted a secondary analysis of data from the randomized and nonrandomized PARTNER trials: 2559 patients who were high-risk (cohort A) or inoperable (cohort B). The patients' mean age was 84 years; 52% were men.

At baseline, women had significantly lower rates of hyperlipidemia, diabetes, smoking, and renal disease — but significantly higher Society of Thoracic Surgeons Predicted Risk of Mortality scores (mean, 11.9% vs. 11.1%). After TAVR, women had significantly higher rates of vascular complications (17.3% vs. 10.0%) and major bleeding (10.5% vs. 7.7%), but a si…

Reviewing Author

Beat J. Meyer, MD

Disclosures

Leadership positions in professional societiesBern Heart Foundation (President); International Academy of Medicine, Bern, Switzerland (Director)

Beat J. Meyer, MD

Disclosures

Leadership positions in professional societiesBern Heart Foundation (President); International Academy of Medicine, Bern, Switzerland (Director)

Sex Differences in Outcomes After TAVR

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Reviewing Author