How Should Antibiotics Be Prescribed to Hospitalized Patients with Community-Acquired Pneumonia?

Early administration of antibiotics and use of objective criteria to transition from intravenous to oral therapy are beneficial.

Investigators systematically evaluated published literature to assess associations between mortality in adults hospitalized with community-acquired pneumonia (CAP) and several key aspects of antibiotic therapy.

For time to antibiotic initiation, eight observational studies showed that antibiotic initiation within 4 to 8 hours of hospital arrival was associated with lower mortality.
For initial antibiotic selection in hospitalized CAP patients, results were inconclusive. Systematic review revealed conflicting results of the two randomized controlled trials (RCTs) and inconsistent results from prospective cohorts in which β-lactam monotherapy was compared with β-lactam-plus-macrolide therapy; recent RCT data for this comparison suggested that β…

Reviewing Authors

Joanna Bonsall, MD, PhD

Daniel D. Dressler, MD, MSc, SFHM, FACP

Disclosures

RoyaltiesMcGraw-Hill; Elsevier

Editorial BoardsMedical Clinics of North America; Caribbean Medical Journal International Advisory Panel (2021–2026)

Daniel D. Dressler, MD, MSc, SFHM, FACP

Disclosures

RoyaltiesMcGraw-Hill; Elsevier

Editorial BoardsMedical Clinics of North America; Caribbean Medical Journal International Advisory Panel (2021–2026)

How Should Antibiotics Be Prescribed to Hospitalized Patients with Community-Acquired Pneumonia?

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Reviewing Authors