A Risk Prediction Score for Parkinson Disease?

Older age at diagnosis, poor balance, and significant cognitive issues translate to a worse outcome in Parkinson disease.

To develop a simple, outcomes-based prognostic model for Parkinson disease (PD), researchers tested a composite outcome measure in a clinic-based group of newly diagnosed PD patients recruited for another study in the Netherlands. External validation was performed in a separate group of community-based, newly diagnosed PD patients in the United Kingdom. The primary outcome was unfavorable prognosis, defined as postural instability, dementia, or death at or before the 5-year assessment (or at the latest clinical assessment if prior to the 5-year follow-up). To construct the model, the researchers used a backward selection strategy that focused on baseline characteristics.

Older age, higher (worse) Unified Parkinson's Disease Rating Scale moto…

Reviewing Author

Michael S. Okun, MD

Disclosures

Consultant/Advisory BoardParkinson’s Foundation; Tourette Association of America

Speaker’s BureauMedscape/WebMD CME, Movement Disorders Society CME, American Academy of Neurology CME

RoyaltiesBooks4Patients; Demos; Cambridge; Taylor and Francis; Robert Rose; Public Affairs

Grant/Research SupportNational Institutes of Health; Parkinson’s Foundation; Tourette Association of America; University of Florida Foundation

Editorial BoardsTremor and Other Hyperkinetic Movements; JAMA Neurology

Leadership Positions in Professional SocietiesParkinson’s Foundation (Medical Advisor)