Patients with relapsing multiple sclerosis had increased risk for worsening disability when RNFL was <87 microns.
Optical coherence tomography (OCT) measures thickness of the retinal nerve fiber layer (RNFL) around the optic nerve and ganglion cells within the macula. OCT is frequently used in research studies; its role in clinical decision making for multiple sclerosis (MS) care has not been defined.
Investigators in this prospective, multicenter, international cohort study measured RNFL thickness in 879 participants (age, ≥16) diagnosed with clinically isolated syndrome (74 patients) or MS (relapsing remitting MS [RRMS], 664; secondary progressive MS, 83; primary progressive MS, 58). Patients with clinical history of optic neuritis (ON) or intra-eye RNFL asymmetry suggestive of subclinical ON were excluded. Disability worsening was compared in patient…
Reviewing Author
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)