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In patients being treated for long-term stroke prevention with aspirin, patients who have a new ischemic event while taking aspirin are frequently considered to have aspirin failure. One potential mechanism for aspirin failure is aspirin resistance, operationally defined as high amounts of residual platelet aggregation despite aspirin administration.
To examine the potential effect of aspirin resistance on stroke severity, researchers evaluated 310 patients admitted within 48 hours after stroke onset who were taking aspirin for at least the 7 previous days. High residual platelet reactivity (HRPR) on aspirin treatment was assessed using the VerifyNow assay. The researchers assessed correlations of assay values with stroke severity, as measur…