Genetic Risk Factors Are Common in Pediatric Pancreatitis

PRSS1 mutations were associated with progression of acute recurrent pancreatitis to chronic pancreatitis.

Risk factors associated with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) in children are unclear. To identify these factors in pediatric ARP and CP, investigators conducted a multinational, cross-sectional study of 301 children, of whom 155 had ARP (≥2 episodes of acute pancreatitis) and 146 had CP.

The key findings were as follows:

Most children with CP (84%) presented with ARP.
The median time of progression from first episode of AP to CP was 1 year.
A family history of CP was more common in children with CP than in those with ARP.
Gene mutations associated with pancreatitis were more common in children with CP than in those with ARP (P<0.001).
CFTR mutations were the most common mutations in ARP.
PRSS1 mutations were the mo…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Genetic Risk Factors Are Common in Pediatric Pancreatitis

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Reviewing Author