The Impact of Repeat High-Dose Split-Virus Influenza Vaccination

In a subset analysis of an industry-sponsored study, repeat vaccination with high-dose influenza vaccine was associated with significantly higher vaccine efficacy compared with repeated administration of standard-dose vaccine.

A study of vaccination with a whole-virus influenza vaccine published in 1997 did not demonstrate a difference in efficacy between the initial vaccination and repeated annual vaccinations. However, subsequent observations have renewed an interest in this topic. To investigate whether a carryover effect of initial high-dose (HD) vaccination exists, researchers took advantage of second-year reenrollment offered to participants in a recent study that demonstrated higher antibody responses among adults aged ≥65 years who received a high-dose split-virus (IIV-HD) vaccine compared with a standard dose of same preparation (IIV-SD). This trial was supported by Sanofi Pasteur, the manufacturer of IIV-HD.

Among the original 14,500 participants in 2011…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

The Impact of Repeat High-Dose Split-Virus Influenza Vaccination

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Reviewing Author