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In small uncontrolled studies, a “cocktail” of three different monoclonal antibodies — Z-Mapp — benefited patients with Ebola virus disease; however, Z-Mapp is expensive and slow to produce. Now, an international team reports that they have isolated a single monoclonal antibody (from a long-term survivor of Ebola virus disease) that neutralizes, in vitro, many different strains of Ebola virus that have emerged during the past 40 years. Subsequent in vivo studies in monkeys showed that the antibody had a powerful protective effect even when administered 5 days after exposure to the virus.
Another international team reported that a small molecule called GS-5734 greatly inhibits in vitro replication of Ebola virus. Subsequent studies in monkeys…