Where Are Amyloid Changes Seen First in Alzheimer Disease?

Low amyloid beta-42 levels in the cerebrospinal fluid may be the first sign of underlying Alzheimer disease pathology.

Both low amyloid beta-42 levels in the cerebrospinal fluid (CSF Aβ42) and amyloid deposition on positron emission tomography (PET) are biomarkers in Alzheimer disease. Because the temporal relation between the two amyloid biomarkers is not well established, researchers conducted a prospective study of 437 older adults (aged 55–90 years) with normal cognition or mild cognitive impairment, identified from the Alzheimer's Disease Neuroimaging Initiative database. Amyloid deposition was determined by low CSF Aβ42 levels (<182.4 ng/L) and elevated 18-F-florbetapir standardized uptake ratios (>0.83) on PET imaging at baseline. Rates of amyloid accumulation were determined by changes in 18-F-florbetapir PET imaging at 1 to 4 years of follow-up. Pr…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Where Are Amyloid Changes Seen First in Alzheimer Disease?

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Reviewing Author