Nonoccupational Postexposure Prophylaxis for HIV: Updated Guidelines

Some helpful updates have been made to these guidelines.

Sponsoring Organization: Centers for Disease Control and Prevention, U.S. Department of Health and Human Services

Target Audience: Clinicians who see patients for nonoccupational postexposure prophylaxis (nPEP) in the United States

Background

This guideline updates the 2005 version. Because no randomized trials of nPEP have been done, recommendations are based on data from animal transmission models, perinatal clinical trials, and observational and case studies.

Key Recommendations

Consider nPEP for individuals who present for medical care within 72 hours after sexual, mucosal, or percutaneous exposure to potentially infectious bodily fluids from an HIV-infected person.
Make decisions about use of nPEP on a case-by-case basis when the source's HI…

Reviewing Authors

Kevin Ard, MD, MPH

Rajesh T. Gandhi, MD

Disclosures

Grant/Research SupportNIH

Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)

Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)