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Persistence of Ebola virus in immune-privileged sites, such as semen and the aqueous humor, has been well documented. Investigators now report relapse with potentially life-threatening meningoencephalitis in a nurse 9 months after apparent recovery from acute Ebola infection.
The 39-year-old female nurse from Scotland, who was infected in Sierra Leone in 2014, had received experimental antiviral therapies in London and had clinical improvement and undetectable Ebola virus RNA in peripheral blood. Six months after discharge, she developed polyarthralgia controlled with nonsteroidal anti-inflammatory drugs; Ebola virus RNA was not detected in blood. Nine months after discharge, she developed severe headache, fever, photophobia, and vomiting; E…