According to a new model, almost one third of breast cancers among U.S. white women could be prevented by adopting healthy lifestyles.
Modifiable risk factors for breast cancer include postmenopausal obesity, menopausal estrogen-progestin therapy (EPT), and alcohol consumption. Nonmodifiable risk factors evaluated in this study include family history of breast cancer, age at menarche and menopause, parity, breast density, atypical hyperplasia, and single nucleotide polymorphisms (SNPs; genetic markers associated with risk). To predict absolute risk for invasive breast cancer in U.S. white women, investigators developed a model that incorporated 92 SNPs plus epidemiologic elements (family history, anthropometric features, and menstrual, reproductive, and lifestyle factors).
When all risk factors were included, average absolute risk ranged from 4.4% to 23.5%. Overall, average…
Reviewing Authors
DisclosuresRoyaltiesUpToDate
Grant/Research SupportMerck, Mithra, Medicines360
Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health
DisclosuresRoyaltiesUpToDate
Grant/Research SupportMerck, Mithra, Medicines360
Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health
DisclosuresLeadership Positions in Professional SocietiesAssociation of Women Surgeons (Member, Publications Committee)
DisclosuresLeadership Positions in Professional SocietiesAssociation of Women Surgeons (Member, Publications Committee)