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Post-thrombotic syndrome is a common complication of deep venous thrombosis (DVT) that causes symptoms ranging from pain and swelling to ulceration. Elastic compression stockings often are prescribed to prevent this complication, but the most effective duration of treatment is unclear. Researchers in the Netherlands conducted a noninferiority trial of compression stocking use in 518 patients who had adhered to compression stocking therapy and had not developed post-thrombotic syndrome during 1 year after experiencing proximal lower-extremity DVT. Half of the participants were told to stop wearing compression stockings at 1 year, and the other half were told to continue therapy for another year.
In intent-to-treat analysis, incidence of post-…